Mutation in the GCH1 gene with dopa-responsive dystonia and phenotypic variability

نویسندگان

  • Elsa Krim
  • Jerome Aupy
  • Fabienne Clot
  • Mickael Bonnan
  • Pierre Burbaud
  • Dominique Guehl
چکیده

Dopa-responsive dystonia (DRD) is an autosomal dominant neurologic disorder characterized by incomplete penetrance and high variability of its phenotypic expression. The usual phenotype is defined by early-onset isolated dystonia, predominant in the lower limb, with marked diurnal fluctuations and a dramatic and sustained response to low doses of L-DOPA. We report 2 members of the same family (mother and daughter) with a nonsense heterozygous mutation (c.706G>T; p.Glu236*) in the GCH1 gene and having DRD with phenotypic variability.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2018